Menopause / Hot Flashes

 

EPA Omega 3

Effects of ethyl-eicosapentaenoic acid omega-3 fatty acid supplementation on hot flashes and quality of life among middle-aged women

https://journals.lww.com/menopausejournal/Abstract/2009/16020/Effects_of_ethyl_eicosapentaenoic_acid_omega_3.22.aspx

“Supplementation with E-EPA omega-3 fatty acid reduced HF frequency and improved the HF score relative to placebo. These results need to be confirmed by a clinical trial specifically designed to evaluate HFs in more symptomatic women.”

Black Cohosh – side effects aren’t good

Pilot Evaluation of Black Cohosh for the Treatment of Hot Flashes in Women

The reduction in mean daily hot flash frequency was 50% (95% CI, 34%–65%), while weekly hot flash scores were reduced 56% (95% CI, 40%–71%) at completion of the study. Overall, patients reported less trouble with sleeping, less fatigue, and less abnormal sweating. No patients stopped therapy because of adverse effects. Conclusions. Black cohosh appeared to reduce hot flashes and had a low toxicity. The efficacy found in this trial seems to be more than would be expected by a placebo effect (20%–30% hot flash reduction in previous trials).

Evening Primrose Oil

The effect of oral evening primrose oil on menopausal hot flashes: a randomized clinical trial

https://link.springer.com/article/10.1007/s00404-013-2852-6

“The application of oral evening primrose oil compared with placebo for controlling hot flashes may decrease more the intensity of attacks as well as ameliorating the HFRDIS score.”

Licorice Root

Effects of Licorice on Relief and Recurrence of Menopausal Hot Flashes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832176/

“Findings showed that licorice root is effective in reducing the frequency and severity of hot flash. Comparing the mean frequencies of hot flash in the weeks before the therapy, 8 weeks of therapy and 4 weeks of follow-up through ANOVA with repeated measurements, there was found a significant difference in the licorice group and no difference in the placebo group. In other words, licorice could decrease daily hot flash frequencies during 8 weeks while no decrease was found at the same period in the other group. In addition, the significant difference in the licorice group was seen from the 1^st week, increased significantly in time and continued until the 2^nd week after the therapy as the recurrence took place from this stage.”

Anise – Pimpinella Anisum

The Study on the Effects of Pimpinella anisum on Relief and Recurrence of Menopausal Hot Flashes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813162/

“In general, the results showed that Pimpinella anisum had desirable effects on severity and frequency of hot flashes.”

Sage Extract

The effect of Saliva officinalis extract on the menopausal symptoms in postmenopausal women: An RCT

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686654/

“It was concluded that Saliva officinalis were effective to change the severity of some of the menopausal symptoms in postmenopausal women.”

Fenugreek Seed 

Probable effects of fenugreek seed on hot flash in menopausal women

https://pesquisa.bvsalud.org/portal/resource/pt/emr-78018

“Use of fenugreek seed for four and eight weeks caused to decrease number of hot flashes and vasomotors, but the effect was smaller than that of HRT.”

Vitamin E

The Effect of Vitamin E on Hot Flashes in Menopausal Women

https://www.karger.com/Article/Abstract/106491

Based on our trial, vitamin E is recommended for the treatment of hot flashes.

Circumin + Vitamin E

The effect of oral capsule of curcumin and vitamin E on the hot flashes and anxiety in postmenopausal women: A triple blind randomised controlled trial

https://www.sciencedirect.com/science/article/abs/pii/S0965229919313068

“The results of this study showed that oral intake of curcumin and vitamin E significantly reduced hot flashes in postmenopausal women but had no significant effect on anxiety, sexual function and menopausal symptoms.”

 

Research on Autism 2023

Initial research shows that white matter develops in the brain causing symptoms.  White matter can be reduced by increasing blood flow to the brain.

You need to research Vinpocetine as an option. I just ordered some for myself: https://www.amazon.com/gp/product/B00A0IM72G/

Also: Vinpocetine has potential efficacy in treating patients with this mutation and possibly other GABRB3 mutations or other forms of epilepsy. Additional studies on pharmacokinetics, potential drug interactions, and safety are needed.

Also these: https://msngroup.aimoo.com/APeacefulPlace/pesticideexpose.msnw-action=get_message&mvie[…]ssage=448&LastModified=4675695236683480395&all_topics=1.htm

Food needs to be observed for reactivity:

"Parents and autism support groups commonly report that autistic episodes are triggered when these children eat wheat, corn, sugar, apples, bananas, chocolate, cheese, and other dairy products. Because many of these “trigger” foods are high in phenolic amines (e.g., dopamine and serotonin) that depend on sulfate for excretion,"

https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=7079d3e57a157b6bc866682a6a0ea90e86698bd4

Increase their sulfur substrate, e.g., via magnesium sulfate (Epsom salts) in bathwater and/or careful doses in orange juice. Oral magnesium sulfate, which is poorly absorbed, draws water into the intestines, potentially causing diarrhea; whereas, well-absorbed magnesium taurate provides magnesium as well as sulfur from taurine. Almost half of autistic children and adults benefitwhen given oral vitamin B6 plus magnesium (optimal daily dose on average: 8 mg vitamin B6 /lb body weight plus 4 mg magnesium/lb). Other good sources of sulfur are cabbage, onions, garlic, dried fruit, oral supplements like whey protein and methylsulfonylmethane (MSM), and a high-protein diet. Cysteine supplements, however, appear unsafe. Quig noted that high doses of cysteine (e.g., 500 mg 3 times daily) may transport mercury into the brain. Pangborn warned that a sudden influx of cysteine may mobilize toxins the body is not ready or able to excrete.

Here is an FDA approved solution: DMSA

"An epidemiology study by Windham et al. [2] found that the amount of airborne pollutants, and especially mercury, correlated with an increased risk for autism. A study by DeSoto and Hitlan [3] found that blood levels of mercury did significantly correlate with the diagnosis of autism. A small study by Adams et al. [4] found that children with autism had a 2-time higher level of mercury in their baby teeth than typical children. A study by Bradstreet et al. [5] investigated the body burden of toxic metals by giving dimercaptosuccinic acid (DMSA), an oral chelation medication approved by the FDA for treating infantile lead poisoning. They found that the children with autism excreted 3.1 times as much mercury into their urine (which is where DMSA is excreted), P < .0002, but lead and cadmium levels were not significantly different. Overall there is some evidence to suggest that mercury and possibly other toxic metals are related to the etiology of autism."

https://www.acam.org/blogpost/1092863/ACAM-Integrative-Medicine-Blog?tag=&DGPCrSrt=&DGPCrPg=13

https://warddeanmd.com/dmsa-and-detoxing-heavy-metals/

warddeanmd.comwarddeanmd.com

DMSA and Detoxing Heavy Metals

DMSA and Detoxing Heavy Metals

By Ward Dean, M.D.

In several previous issues of Vitamin Research News, both intravenous and oral chelation therapy with EDTA we(...)

Jul 30th, 2012

I knew this would be a solution: Probiotics!

https://www.tandfonline.com/doi/abs/10.1080/1028415X.2017.1347746

Fish oil + Fish is good.  I think anything anti-inflammatory would be a good diet.

https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-11-22#Tab11

BioMed CentralBioMed Central

Gastrointestinal flora and gastrointestinal status in children with autism – comparisons to typical children and correlation with autism severity - BMC Gastroenterology

Background Children with autism have often been reported to have gastrointestinal problems that are more frequent and more severe than in children from the general population. Methods Gastrointestinal flora and gastrointestinal status were assessed from stool samples of 58 children with Autism Spectrum Disorders (ASD) and 39 healthy typical children of similar ages. Stool testing included bacterial and yeast culture tests, lysozyme, lactoferrin, secretory IgA, elastase, digestion markers, short chain fatty acids (SCFA's), pH, and blood presence. Gastrointestinal symptoms were assessed with a modified six-item GI Severity Index (6-GSI) questionnaire, and autistic symptoms were assessed with t… Show more

https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-11-22#Tab11

Vitamin D / Moderate Sun Exposure

https://www.ingentaconnect.com/content/wk/mdpsy/2015/00000022/00000001/art00003

Suramin study: https://onlinelibrary.wiley.com/doi/full/10.1002/acn3.424

https://health.ucsd.edu/news/topics/Suramin-Autism/Pages/default.aspx

https://www.liebertpub.com/doi/abs/10.1089/acm.2010.0146

dimethylglycine and a combination of a large dose of vitamin B6 (pyridoxal HCl) and magnesium

https://www.sciencedirect.com/science/article/abs/pii/S0149291813001781

combination of the flavonoids luteolin and quercetin seemed to be effective in reducing ASD symptoms, with no major adverse effects.

sciencedirect.comsciencedirect.com

An Open-Label Pilot Study of a Formulation Containing the Anti-Inflammatory Flavonoid Luteolin and Its Effects on Behavior in Children With Autism Spectrum Disorders

Accumulating evidence suggests an association between autism spectrum disorders (ASD) and inflammation in brain regions related to cognitive function.…