Initial research shows that white matter develops in the brain causing symptoms. White matter can be reduced by increasing blood flow to the brain.
You need to research Vinpocetine as an option. I just ordered some for myself: https://www.amazon.com/gp/product/B00A0IM72G/
Also: Vinpocetine has potential efficacy in treating patients with this mutation and possibly other GABRB3 mutations or other forms of epilepsy. Additional studies on pharmacokinetics, potential drug interactions, and safety are needed.
Food needs to be observed for reactivity:
"Parents and autism support groups commonly report that autistic episodes are triggered when these children eat wheat, corn, sugar, apples, bananas, chocolate, cheese, and other dairy products. Because many of these “trigger” foods are high in phenolic amines (e.g., dopamine and serotonin) that depend on sulfate for excretion,"
Increase their sulfur substrate, e.g., via magnesium sulfate (Epsom salts) in bathwater and/or careful doses in orange juice. Oral magnesium sulfate, which is poorly absorbed, draws water into the intestines, potentially causing diarrhea; whereas, well-absorbed magnesium taurate provides magnesium as well as sulfur from taurine. Almost half of autistic children and adults benefitwhen given oral vitamin B6 plus magnesium (optimal daily dose on average: 8 mg vitamin B6 /lb body weight plus 4 mg magnesium/lb). Other good sources of sulfur are cabbage, onions, garlic, dried fruit, oral supplements like whey protein and methylsulfonylmethane (MSM), and a high-protein diet. Cysteine supplements, however, appear unsafe. Quig noted that high doses of cysteine (e.g., 500 mg 3 times daily) may transport mercury into the brain. Pangborn warned that a sudden influx of cysteine may mobilize toxins the body is not ready or able to excrete.
Here is an FDA approved solution: DMSA
"An epidemiology study by Windham et al. [2] found that the amount of airborne pollutants, and especially mercury, correlated with an increased risk for autism. A study by DeSoto and Hitlan [3] found that blood levels of mercury did significantly correlate with the diagnosis of autism. A small study by Adams et al. [4] found that children with autism had a 2-time higher level of mercury in their baby teeth than typical children. A study by Bradstreet et al. [5] investigated the body burden of toxic metals by giving dimercaptosuccinic acid (DMSA), an oral chelation medication approved by the FDA for treating infantile lead poisoning. They found that the children with autism excreted 3.1 times as much mercury into their urine (which is where DMSA is excreted), P < .0002, but lead and cadmium levels were not significantly different. Overall there is some evidence to suggest that mercury and possibly other toxic metals are related to the etiology of autism."
https://www.acam.org/blogpost/1092863/ACAM-Integrative-Medicine-Blog?tag=&DGPCrSrt=&DGPCrPg=13
https://warddeanmd.com/dmsa-and-detoxing-heavy-metals/
warddeanmd.comwarddeanmd.com
DMSA and Detoxing Heavy Metals
DMSA and Detoxing Heavy Metals
By Ward Dean, M.D.
In several previous issues of Vitamin Research News, both intravenous and oral chelation therapy with EDTA we(...)
Jul 30th, 2012
I knew this would be a solution: Probiotics!
https://www.tandfonline.com/doi/abs/10.1080/1028415X.2017.1347746
Fish oil + Fish is good. I think anything anti-inflammatory would be a good diet.
https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-11-22#Tab11
BioMed CentralBioMed Central
Gastrointestinal flora and gastrointestinal status in children with autism – comparisons to typical children and correlation with autism severity - BMC Gastroenterology
Background Children with autism have often been reported to have gastrointestinal problems that are more frequent and more severe than in children from the general population. Methods Gastrointestinal flora and gastrointestinal status were assessed from stool samples of 58 children with Autism Spectrum Disorders (ASD) and 39 healthy typical children of similar ages. Stool testing included bacterial and yeast culture tests, lysozyme, lactoferrin, secretory IgA, elastase, digestion markers, short chain fatty acids (SCFA's), pH, and blood presence. Gastrointestinal symptoms were assessed with a modified six-item GI Severity Index (6-GSI) questionnaire, and autistic symptoms were assessed with t… Show more
https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-11-22#Tab11
Vitamin D / Moderate Sun Exposure
https://www.ingentaconnect.com/content/wk/mdpsy/2015/00000022/00000001/art00003
Suramin study: https://onlinelibrary.wiley.com/doi/full/10.1002/acn3.424
https://health.ucsd.edu/news/topics/Suramin-Autism/Pages/default.aspx
https://www.liebertpub.com/doi/abs/10.1089/acm.2010.0146
dimethylglycine and a combination of a large dose of vitamin B6 (pyridoxal HCl) and magnesium
https://www.sciencedirect.com/science/article/abs/pii/S0149291813001781
combination of the flavonoids luteolin and quercetin seemed to be effective in reducing ASD symptoms, with no major adverse effects.
sciencedirect.comsciencedirect.com
An Open-Label Pilot Study of a Formulation Containing the Anti-Inflammatory Flavonoid Luteolin and Its Effects on Behavior in Children With Autism Spectrum Disorders
Accumulating evidence suggests an association between autism spectrum disorders (ASD) and inflammation in brain regions related to cognitive function.…
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